Director, Clinical Operations Lead

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Why Join Us?

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy.

• Collaborative Culture: Be part of a diverse team dedicated to your professional growth.

• Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Role Overview

We are seeking a Director, Clinical Operations Lead to support our Clinical Operations team. The Director, Clinical Operations Lead will be responsible for the oversight, execution, and operational management of global clinical trials in support of our clinical development programs.

Schedule: 8:00 AM – 5:00 PM; Monday to Friday
Reports to: Vice President, Clinical Operations EU
Location: Fully Remote

Salary Range: $215,000.00 - $260,000.00

Basic Qualifications:

• Bachelor’s degree

• 10+ years of demonstrated leadership of global clinical operations in the pharmaceutical or biotechnology industry including clinical trial oversight, vendor management, and cross-functional study leadership

• Experience in oncology, cell and/or gene therapy, or other complex biologic clinical development programs

Preferred Qualifications:

• Master’s Degree, preferably in life science, nursing, or similar

• Demonstrated ability to drive process improvements and operational excellence initiatives

• Ability to understand and navigate complex clinical development processes and cross-functional interdependencies

• Strong analytical and problem-solving skills with the ability to assess operational impact across broader cross-functional environments

• Ability to operate effectively in a fast-paced and evolving clinical development environment

In this role you will:

• Lead global clinical trial execution and operational delivery across internal and external stakeholders

• Provide oversight of CROs, vendors, and clinical trial partners to ensure quality, compliance, timelines, and budget objectives are achieved

• Drive risk identification, issue escalation, and mitigation planning across assigned studies

• Support study start up, site feasibility, enrollment, and operational execution activities

• Partner cross-functionally with Clinical Development, Regulatory, Safety, Biometrics, Supply Chain, and external vendors

• Contribute to SOP development, process optimization, inspection readiness, and operational excellence initiatives

• Mentor junior Clinical Operations team members as applicable

Qualified candidates will participate in a structured interview process, which includes:

• An initial recruiter phone screen (conducted via video)

• A recruiter-facilitated introduction and interview with the hiring leader and key stakeholders (via video)

• A final-stage interview, which may include an in-person meeting at our U.S. Headquarters in Houston, TX

What do we offer?

At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join Immatics

Comprehensive Benefits:

• Competitive rates for Health, Dental, and Vision Insurance

• 4 weeks of vacation granted up front each year and prorated for first and last year of employment.

• 12 company paid holidays

• 7 days of sick time

• 100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars

• 100% employer-paid short- and long-Term disability coverage

• 401(k) with immediate eligibility and company match…

• The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.

• Partially paid parental leave for eligible employees.

• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.