Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values be audacious, be curious, be authentic, be engaged, and be accountable creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicines toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

The Director of National Accounts (DNA) will serve as Amylyxs primary interface with U.S. payers, supporting appropriate coverage and patient access planning in preparation for a potential future commercial launch of our lead product candidate.

This individual contributor role is responsible for developing and executing Amylyxs national and regional payer engagement strategies to support evidence-based coverage discussions and patient access planning. This role serves as the primary interface with national and regional payers, PBMs, Medicare, Medicaid, and other government customers, while also partnering cross-functionally with Market Access Field Teams, HEOR, Medical Affairs, Patient Services, Sales, and Distribution teams in accordance with company policies and applicable laws and regulations.

We anticipate the start date of the Director National Accounts to be in September 2026.

Territory & Account Alignment

Multiple Director of National Account positions may be filled and will be assigned to accounts based on business needs, customer alignment, and candidate experience and may evolve over time.

While account assignments may change as the organization grows, current planning includes alignment to three broad territories. This role is currently planned to cover WI, MI, OH, WV, KY, TN, IL, IN, IA, MO, KS, OK, AR, LA, MS, AL

Central Region Accounts (Examples may include):

Cigna Group Cigna Healthcare/Evernorth-ESI/Ascent
Prime Therapeutics
Assigned national and regional payer accounts
Assigned State Medicaid Fee-for-Service Programs
Assigned VA/DoD/TRICARE responsibilities

Key Responsibilities

National Payer Strategy & Leadership

Develop and execute national and regional payer strategy across commercial, Medicare Part D/MA-PD, Managed Medicaid, FFS Medicaid, VA/Tricare/DoD, and PBMs to support appropriate coverage and access objectives.
Anticipate payer evidence needs; partner with HEOR and medical teams to inform value evidence and access strategy ahead of potential launches, consistent with approved materials and internal review processes.
Provide strategic input on contracting considerations, distribution networks, coverage considerations, and pharmacy-benefit dynamics.
Analyze policy trends, competitive intelligence, and legislative developments that affect rare disease access; translate insights into strategy.

Executive-Level Payer Engagement

Build and maintain compliant, professional relationships with pharmacy directors, medical directors, policy leaders, and other payer stakeholders involved in evidence review and access decision-making.
Support compliant executive-level discussions regarding coverage policy considerations, prior authorization concepts, utilization management frameworks, and formulary review processes.
Develop customized, >Preference may be given to candidates residing within or near the geographic region they support.
You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

Compensation

The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidates experience, skills, and qualifications, as well as considerations of internal equity.

Estimated Pay Range

$223,000—$265,000 USD

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Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyxs management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Director, National Accounts, Central

Amylyx Pharmaceuticals

Job Description