Principal Scientist II

Job Description Summary

Position Location: onsite, Cambridge, MA
#LI-hybrid

*This role is based in Cambridge, MA. Please only apply if this location is accessible for you.

We are seeking a highly motivated Principal Scientist to join our xDC team and help advance next-generation targeted therapeutic platforms. This role will contribute to the development and expansion of biologics and drug-conjugate infrastructure, with a focus on innovative vectorization strategies, biology-informed payload approaches, and differentiated conjugate designs.
The ideal candidate will bring strong scientific judgment, hands-on technical expertise, and experience working in a collaborative, cross-functional environment. Industry experience in biologics, ADCs, targeted therapeutics, or related modalities is preferred.

Job Description

Key Responsibilities:

• Drive scientific activities supporting the discovery and optimization of next-generation xDC and biologics platforms

• Contribute to the design and evaluation of new vectorization approaches for targeted delivery

• Support the development of payload strategies aligned with disease biology and therapeutic mechanism of action

• Participate in the exploration of differentiated conjugate formats, including multi-payload or combination-based approaches

• Work closely with cross-functional teams across biology, chemistry, protein engineering, pharmacology, translational sciences, and CMC

• Design, execute, and interpret experiments to guide platform and program decisions.

• Identify emerging scientific opportunities and help translate them into actionable research strategies

• Communicate results clearly through presentations, reports, and scientific discussions

• Contribute to external collaborations and technology evaluation efforts as needed

• Maintain awareness of the competitive and scientific landscape in ADCs, biologics, and targeted therapeutic platforms

Essential Requirements:

• Ph.D. in biology, biochemistry, molecular biology, pharmacology, immunology, chemical biology, bioengineering, or a related discipline

• 3–5 years of relevant post-Ph.D. experience, preferably in an industry setting

• Experience with biologics, antibody-drug conjugates, targeted delivery platforms, protein therapeutics, or related modalities

• Strong understanding of disease biology, target selection, mechanism-of-action studies, and translational research principles

• Familiarity with biologics engineering, conjugation strategies, payload biology, or preclinical therapeutic development is preferred

• Demonstrated ability to design rigorous experiments, analyze complex data, and make target="_blank">here.

  
  

  EEO Statement:

  The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

  
  

  Accessibility and reasonable accommodations

  The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

  
  

  Salary Range

  $119,700.00 - $222,300.00

  
  

  Skills Desired

  Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Curious Mindset, Data Analysis, Detail-Oriented, Drug Development, Ethics, Gene Therapy, Immunology, Inventory Management, Machine Learning (ML), Medical Research, Molecular Biology, Python (Programming Language), Science