Principal Scientist - RGM Chemistry

We are looking for a visionary Principal Scientist – RGM Chemistry to lead the discovery, development, and optimization of antibody-oligonucleotide conjugation technologies that power next-generation targeted therapeutics. Sitting at the intersection of bioconjugation chemistry, RNA science, and process innovation, you will set scientific strategy, guide a multidisciplinary team, and translate ground breaking concepts into scalable solutions that advance our therapeutic pipeline. Your deep expertise, collaborative attitude, and passion for mentoring will drive breakthrough medicines from bench to preclinical validation and beyond.

In this role, a typical day might include the following:
- Designing and completing experiments to refine linker chemistry, payload stability, and delivery efficiency for antibody-oligo conjugates
- Analyzing conjugates with HPLC, LC-MS, and bioassays to ensure purity, identity, and functional potency
- Leading project stand-ups, mentoring scientists and research associates, and troubleshooting technical challenges in real time
- Partnering with Process Development and Manufacturing to scale promising conjugation methods for preclinical supply
- Scouting and evaluating emerging bioconjugation or RNA delivery technologies, then proposing >Salary Range (annually)