Senior Data Scientist – Neuroscience Spatial Multi-omics

Job Description

Our Company’s Data, AI & Genome Sciences Department in Cambridge, MA is seeking a Senior Specialist (Senior Scientist), Data Science to join the Translational Neuroscience Analytics team and drive integrative analysis of spatial and single-nucleus multi-omics data from patients with neurodegenerative diseases. The qualified individual will be a motivated data scientist or computational biologist with a track record of developing and applying cutting-edge AI/ML methodologies to extract actionable insights from single-nucleus and spatial multi-omics data. In this role, they will leverage spatially resolved transcriptomics data with single-cell resolution to understand target pathway biology in relation to pathological hallmarks of neurodegenerative diseases, especially Alzheimer’s disease, and integrate this information with single-nucleus multi-omics data from large patient cohorts to enable causal modeling and prediction of target perturbation effects across cell populations of interest. Through these analyses, they will contribute to the evaluation of specific therapeutic hypotheses as well as the identification and placement of biomarkers along the causal cascade from therapeutic target to clinical outcome, ultimately shaping the translational strategies of our neurodegenerative therapeutic programs. They will work alongside with other data scientists and AI/ML scientists in the department to develop and apply innovative approaches to perform such analyses and further integration with clinical, genetic, and other omics data types. They will also be closely collaborating with cross-functional teams of data scientists, bench biologists, and clinical colleagues to drive our neuroscience biomarker and translational strategies.

Primary responsibilities:

• Build and deploy analytic workflows leveraging state-of-art computational methods to analyze spatial multi-omics datasets, with a specific focus on target MOA evaluation and biomarker discovery in neurodegenerative diseases.

• Formulate and drive integration of spatial and single-nucleus multi-omics data to build unified predictive framework capturing the interactions among different CNS cell types (e.g., neurons and microglia).

• Lead data analytic projects to evaluate therapeutic hypothesis, drive precision biomarker discovery, inform translational strategies, and enable >

  Current Employees apply HERE

  Current Contingent Workers apply HERE

  US and Puerto Rico Residents Only:

  Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

  As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

  EEOC Know Your Rights

  EEOC GINA Supplement​

  We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

  Learn more about your rights, including under California, Colorado and other US State Acts

  The salary range for this role is

  $144,800.00 - $227,900.00

  This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

  The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

  We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

  You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

  San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

  Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

  Search Firm Representatives Please Read Carefully
  Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

  Employee Status:

  Regular

  Relocation:

  Domestic

  VISA Sponsorship:

  Yes

  Travel Requirements:

  No Travel Required

  Flexible Work Arrangements:

  Hybrid

  Shift:

  Not Indicated

  Valid Driving License:

  No

  Hazardous Material(s):

  n/a

  Job Posting End Date:

  07/10/2026

  *A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.