Senior Director, Immunology and Translation

CSL Behring is a global biopharmaceutical leader committed to developing innovative therapies for patients with rare and serious diseases. Our Immunology franchise is advancing a diverse pipeline targeting autoimmune and inflammatory conditions across rheumatology, neuroimmunology, and rare dermatology.

Could you be our next Senior Director, Immunology and Translation? The job is in our Waltham MA or Melbourne Australia Office. This is a hybrid position and is onsite three days a week. You will report to the Research Therapeutic Area Lead, Immunology/Transplant and Vaccines.

You will serve as the internal subject matter authority on immunology disease biology, therapeutic target identification, and contribute to the research therapeutic strategy. You will bring end-to-end experience from early ideation through first-in-disease and will partner closely with cross-functional teams including discovery research, translational medicine, clinical development, and business development to shape and advance CSL Behring's immunology pipeline.

This role is critical to CSL Behring's ambition to build a best-in-class immunology franchise and will directly influence portfolio prioritization, target assessment, and early clinical program design.

RESPONSIBILITIES:

Scientific Leadership & Disease Area Expertise

• Serve as the primary scientific expert and internal champion for one or more immunology disease areas, including but not limited to rheumatology, neuroimmunology, and rare dermatology

• Translate deep mechanistic understanding of immune pathology into actionable therapeutic hypotheses and target identification strategies

• Maintain a current and comprehensive view of the competitive landscape, emerging science, and unmet medical need across assigned disease areas

• Represent CSL Behring at key scientific conferences, advisory boards, and KOL meetings; build and leverage a broad external network of thought leaders, clinical investigators, and academic collaborators

Pipeline Development & Asset Progression

• Drive end-to-end asset progression from ideation through first-in-disease designation, integrating scientific rationale, translational endpoints, patient population selection, and regulatory strategy

• Lead or co-lead target and asset evaluation activities including preclinical data package reviews, mechanism-of-action assessments, and translational feasibility analyses

• Provide scientific input to IND-enabling studies, proof-of-concept study designs, and Phase 1/1b protocol development

• Collaborate with the discovery and translational teams to define disease-relevant biomarkers, pharmacodynamic readouts, and patient stratification strategies for early clinical programs

• Actively contribute to R&D programs as a subject matter expert and provide guidance for the clinical development pathway.

• Collaborate with Research Therapeutic Area Lead, RPLs and Immunology core team members to develop and maintain a best-in-class immunology portfolio

Cross-Functional Collaboration & Strategic Input

• Partner with Business Development to assess in-licensing, partnering, and acquisition opportunities within the immunology space, providing scientific due diligence leadership

• Contribute to Target Product Profiles (TPPs), integrated development plans, and portfolio reviews

• Provide disease area expertise to regulatory submissions, clinical study reports, and scientific communications

• Work collaboratively with Medical Affairs, Clinical Operations, and translational colleagues to align development strategies

Qualifications

• MD, DO, or PhD in Immunology, or a closely related discipline

• 12+ years of experience in drug development within a biotech, pharmaceutical, or academic environment

• Demonstrated experience in preclinical to first-in-disease (or equivalent early clinical milestone) in immunology

• Deep scientific expertise in the immunological mechanisms underpinning autoimmune and inflammatory diseases

• Established and active network in drug development with recognized relationships across rheumatology, neuroimmunology, and/or dermatology communities

• Proven track record in evaluating preclinical and clinical assets, including target assessment, data package review, and go/no-go decision-making

• Strong ability to synthesize complex scientific data and communicate strategy clearly to diverse audiences including senior leadership

The expected base salary range for this position at hiring is $302,000 - $350,000. Please note this salary range reflects the minimum and maximum base pay that CSL expects to pay for this position at the time of this posting in MA. Individual base salary for a successful candidate is determined by qualifications, skill level, experience, competencies and other relevant factors. In addition to base salary, total compensation for this role may also include incentive compensation and equity.

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About CSL Behring

CSL Behring is a global biotherapeutics leader driven by our promise to save lives. Focused on serving patients’ needs by using the latest technologies, we discover, develop and deliver innovative therapies for people living with conditions in the immunology, hematology, cardiovascular and metabolic, respiratory, and transplant therapeutic areas. We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives.

CSL Behring operates one of the world’s largest plasma collection networks, CSL Plasma. Our parent company, CSL, headquartered in Melbourne, Australia, employs 32,000 people, and delivers its lifesaving therapies to people in more than 100 countries.

To learn more about CSL, CSL Behring, CSL Seqirus and CSL Vifor visit https://www.csl.com/ and CSL Plasma at https://www.cslplasma.com/.

Our Benefits

For more information on CSL benefits visit How CSL Supports Your Well-being | CSL.

You Belong at CSL

At CSL, Inclusion and Belonging is at the core of our mission and who we are. It fuels our innovation day in and day out. By celebrating our differences and creating a culture of curiosity and empathy, we are able to better understand and connect with our patients and donors, foster strong relationships with our stakeholders, and sustain a diverse workforce that will move our company and industry into the future.

To learn more about inclusion and belonging visit https://www.csl.com/careers/inclusion-and-belonging

Equal Opportunity Employer

CSL is an Equal Opportunity Employer. If you are an individual with a disability and need a reasonable accommodation for any part of the application process, please visit https://www.csl.com/accessibility-statement.