TheSenior Global Medical Affairs Lead (Sr. GMAL)is a pivotal strategic leadership role within AstraZeneca’sOncology Business Unit (OBU). This position sits at the heart of AstraZeneca’s ambition to deliver61 new indication launchesand transform cancer care globally.
Sr. GMALs drive the scientific and strategic agenda that advancespatient experience,closes care gaps, andpromotes health equity, ultimately enabling AstraZeneca to be recognized as#1 in Oncology.
As the accountable strategic medical leader for assignedcomplex indication(s)/asset(s), the Sr. GMAL shapes and delivers theGlobal Medical Strategy, acts as the criticalbridge between R&D and Commercial, and leads the global medical launch readiness journey. The role balances excellence inevidence generationandconfidence building, scaling AstraZeneca’s impact without increasing organizational complexity.
Key Responsibilities
Strategic Medical Leadership for Launch Excellence
- Lead the development, evolution, and delivery of theGlobal Medical Planfor assigned oncology indication(s)/asset(s).
- Set strategic direction, prioritize initiatives, and make evidence-based trade-offs to maximizepatient and business impact.
- Adjust medical strategy proactively in response to external dynamics, insights, and launch KPI performance.
- Define and trackKey Performance Indicators (KPIs)to measure medical strategy impact and identify blockers to launch success.
- Represent Global Medical in key cross-functional forums, including:
- Integrated Business Team (IBT)to help shape Commercial strategy
- Global Product Team (GPT)to inform R&D development, evidence requirements, and lifecycle planning
- LeadMedical Integrated Teams (MITs)to align global, regional, and country teams around launch strategy and execution.
- Serve as a medical decision-maker and ambassador in market engagements, resolving misalignment and reinforcing global priorities.
- Represent Global Medical inLaunch Readiness ReviewsandStrategic Brand Reviews.
- Ensure Medical input shapes:
- Clinical development, including registrational evidence gaps, companion study needs, and Target Product Profiles
- Commercialization strategies, including Tumor Strategic Plans and Business Strategy Plans
- Strengthen global medical capabilities through delegation, coaching, empowerment, and mentorship.
Evidence Generation & Dissemination for Launch Success
- Lead global and regionalgap analysesto identify critical clinical, real-world evidence, and mechanistic evidence needs.
- Develop integrated evidence plans spanningclinical, diagnostic, digital, and real-worldsources.
- Shape the scientific and strategic design ofAZ-sponsored interventional Medical Affairs studiesand own relevant protocol elements.
- ConceptualizeRWE studieswith O2R and align them with the broader evidence strategy.
- Oversee study governance, milestones, and resource allocation to ensure delivery to the highest scientific, ethical, and compliance standards.
- Develop and own theGlobal Publications PlanfromPhase 3 ID onwardsin partnership with the publications team.
- Prepare and deliver compelling scientific communications with credibility and compliance.
- Review and approve selected local/regional medical studies andExternally Sponsored Research (ESR).
- Ensure theMARS visionis reflected across evidence activities through cancer networks, innovative study design, and >
Date Posted
22-Jun-2026Closing Date
05-Jul-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
